解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The immunohistochemical expression of type 1 blood group antigens (type 1 BGAs) was analyzed for 30 cases of testicular germ cell tumors (TGCTs), using monoclonal antibodies against DU-PAN-2, CA19-9, Lewis(a) (Le(a)), and Lewis(b) (Le(b)). DU-PAN-2 was expressed very frequently in all of the embryonal carcinomas (ECs)...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.9.4.845
更新日期:2002-07-01 00:00:00
abstract::Sentinel lymph node (SLN) biopsy is a useful way of assessing axillary nodal status and obviates unnecessary axillary lymph node dissection for patients with node-negative breast cancer. However, SLN can also be located in the internal mammary lymph node (IMN) chain or elsewhere. The practicability and relevance of in...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2002-05-01 00:00:00
abstract::Significance of expression of cytokine induced nitric oxide synthase (iNOS) in colorectal carcinoma remains controversial. The aim of the current study was to elucidate the significance of immunohistochemical expression of iNOS in colorectal carcinoma. The subjects were the 54 patients with colorectal carcinoma, inclu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::Tumour cell proliferation is an important biological prognostic parameter to be considered alongside clinical and histopathological parameters. It has been evaluated by immunohistochemistry using proliferative markers (PCNA, Ki67, etc.) and by flow cytometry considering DNA content, growth fraction (S + G2M) and S-pha...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::Malignant peripheral nerve tumours (MPNT), e.g. malignant schwannoma, represent a relatively rare tumour entity which is usually regarded as a member of the group of soft-tissue sarcomas and treated accordingly. For chemotherapeutic approaches in metastasised disease, ifosfamide and doxorubicin have been identified as...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::The aim of this study was to evaluate HSP27 expression in fetal, normal and inflamed oral mucosal epithelium and in oral premalignant epithelial lesions and in their ensuing invasive cancers. In developing human oral epithelia, immunoreactions for HSP27 were moderately observed in suprabasal keratinocytes of palate an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5), intermediate (n=6...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Several investigators have demonstrated that TGF-beta stimulated clone-22 (TSC-22) regulates cell growth and differentiation, and cell death. TSC-22 is a putative transcriptional regulator containing a leucine zipper-like structure and a nuclear export signal. We previously showed the cytoplasmic localization of TSC-2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Moreover, some authors reported that PTX suppresses spontaneous cytotoxicity of peripheral blood mononuclear cells (PBMC) ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.9.2.423
更新日期:2002-03-01 00:00:00
abstract::This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's propor...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Phosphatidylinositol 3 kinases (PI-3 kinases) play a crucial role in the inositol phospholipid signaling pathway. The effect of wortmannin, an inhibitor of PI-3 kinases, on the suppression of thermotolerance development was investigated in the temperature-sensitive cell line tsAF8. When wortmannin was added immediatel...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Activation of ras genes and human papilloma virus (HPV) infection have been extensively described in cervical carcinomas while information concerning their implication in premalignant lesions of the cervix is limited. We investigated the incidence of K-ras codon 12 point mutations and HPV infection in cases of cervici...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The objective of this study was to examine how splenectomy affects the immune response, particularly T cells, in chemically-induced mammary tumors. Female rats were splenectomized and then exposed to 9,10-dimethyl-1,2-benz(a)anthracene (DMBA) to induce mammary tumors. Splenectomy significantly decreased the rate of tu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.9.1.185
更新日期:2002-01-01 00:00:00
abstract::Splenic metastasis from a lung cancer is infrequently noted, however, the pattern of the metastasis has not been studied, thus we conducted a retrospective study. Twelve of the consecutive 997 patients with lung cancer, who were admitted to our division, developed splenic metastasis. The pattern of splenic metastasis ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1239
更新日期:2001-11-01 00:00:00
abstract::One of the most important clinical problems in the treatment of human solid carcinoma is the intrinsic/acquired resistance. Cisplatin is a platinum compound that is one of the most effective agents in clinic. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1285
更新日期:2001-11-01 00:00:00
abstract::The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1333
更新日期:2001-11-01 00:00:00
abstract::Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.6.1375
更新日期:2001-11-01 00:00:00
abstract::The expression of the DNA mismatch repair proteins hMSH2 and hMLH1 and p21(waf1) the cyclin G1 inhibitor, may determine response of adult cancers to anti-cancer drugs, that include alkylating agents and platinum-based drugs. The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.965
更新日期:2001-09-01 00:00:00
abstract::The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.1027
更新日期:2001-09-01 00:00:00
abstract::Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy. The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV. Oral chemotherapy with UFT plus L...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.1079
更新日期:2001-09-01 00:00:00
abstract::The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (L...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.5.1133
更新日期:2001-09-01 00:00:00
abstract::The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/microl after CTX were randoml...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.767
更新日期:2001-07-01 00:00:00
abstract::Resistance to chemotherapeutic agents is a major problem for successful cancer treatment. P-glycoprotein (Pgp), a product of the multidrug resistance (MDR)1 gene expressed in cancer cells, is one of the mechanism of MDR. However, there are few reports regarding the effects of Pgp on prognosis of colorectal cancer (CRC...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.815
更新日期:2001-07-01 00:00:00
abstract::Three cases of benign pelvic tumors are presented (2 leiomyomas and 1 fibroma). All three tumors were suspected of being malignant neoplasms because they were visualized as heterogeneous high signal intensity on T2-weighted images, and thus they were difficult to diagnose preoperatively. One of the leiomyomas was loca...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.867
更新日期:2001-07-01 00:00:00
abstract::Few studies on sarcomas have examined the relationships between microsatellite alterations in particular loci, tumor prognosis and tumorigenesis, because sarcomas are uncommon and those prognoses can be confounded by coexisting factors, such as tumor site. We studied the relationship between microsatellite alterations...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.4.917
更新日期:2001-07-01 00:00:00
abstract::We investigated cell susceptibility to hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines (RYSTs) and attempted to correlate this with the known potentially relevant molecular determinants of apoptosis, p53 protein status, Bcl-2 family of proteins and heat shock proteins (Hsp). Parent cell line, NMT-1...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.3.501
更新日期:2001-05-01 00:00:00
abstract::The aim of this study is to assess, in squamous cell carcinoma of the cervix, the expression of pan-ras, c-myc and tp53 at protein level using an immunohistochemical (IHC) staining method. One hundred and seven patients with squamous cell carcinoma of the cervix were recruited. Fifty-four patients were of stage 1B/2A ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::We investigated whether or not the mitochondrial genotypes affect radiation-induced micronucleus (MN) formation. For that purpose, the rho+, KT1 and rho0 human osteosarcoma cell lines were used, which carry the wild-type mitochondrial DNA (mtDNA), the tRNALys mutant mtDNA and no mtDNA, respectively. Despite no signifi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.3.615
更新日期:2001-05-01 00:00:00
abstract::Early detection of transitional cell carcinoma (TCC) of the urinary bladder is essential for effective treatment. While several serum markers have been evaluated, none have been widely accepted for practical clinical use. Thus, urinary markers have been introduced and investigated to detect the evidence of bladder can...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.3.669
更新日期:2001-05-01 00:00:00
abstract::Patients with brain metastases in disseminated non-seminomatous germ cell cancer of the testis are treated by combined modality, e.g., cisplatin-containing chemotherapy, whole brain irradiation and/or surgical excision. However, cure rates of patients refractory to that standard treatment are low (5-year survival rate...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.2.219
更新日期:2001-03-01 00:00:00
abstract::The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.2.279
更新日期:2001-03-01 00:00:00
abstract::We present a case of resected hepatocellular carcinoma (HCC) which invaded the gallbladder with a metastasis to a lymph node. It was extremely difficult to make a differential diagnosis between HCC and gallbladder cancer preoperatively. A 68-year old man was admitted to hospital with complaint of a fever. Ultrasonogra...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.8.2.331
更新日期:2001-03-01 00:00:00
abstract::Platinum compounds and vinorelbine (VNB) are active in the treatment of non-small cell lung cancer (NSCLC), but moderate toxicity has been reported. The aims of the present study were to assess activity and tolerability of low dose carboplatin (CBDCA): 4.5 AUC according to Calvert formula on day 1, combined with vinor...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or.8.2.381
更新日期:2001-03-01 00:00:00
abstract::We compared effects of a high fat diet and a carcinogen on cellular elements of the spleen and mammary gland tumors in rats. Animals were fed a 15% olive-oil diet and a group of them were exposed to a carcinogen, dimethylbenz(a)anthacene (DMBA), in two doses of 10 mg/rat. Results of the experiments were evaluated afte...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.2.435
更新日期:2001-03-01 00:00:00
abstract::The aim of this study is to evaluate characteristics in lung cancer patients with chronic obstructive pulmonary disease (COPD). Among 966 lung cancer patients admitted to our division over a period of 24 years, 73 patients were diagnosed as having COPD. There were 68 (93.2%) men and 5 women; of the tumors 43 (58.9%) w...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::A patient who had undergone radical gastrectomy for synchronous gastric cancer (T(1)N(0)M(0), stage I) and duodenal cancer (Tis, stage 0) in November 1987 was found to have esophageal cancer in November 1994, and underwent radical thoracolaparotomy at our hospital (T(1)N(0)M(0), stage I). After follow-up for about 3.5...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::The growth of supportive tissue during the progression of solid tumors is an absolute requirement for the nourishment of the tumor. The blockade of this proliferative response of normal tissues to the growing tumor should hence inhibit tumor progression. We have shown earlier, that the heparinoid pentosan polysulfate ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The objective of the study was to investigate the dynamic changes of cortisol and soluble TNF-alpha p-55 and p-75 receptors in serum of advanced cancer patients during 24 h. The examined group consisted of 42 patients suffering from advanced gastrointestinal neoplasms (colorectal, gastric and pancreatic cancer). Serum...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.8.1.207
更新日期:2001-01-01 00:00:00
abstract::Previous reports showed that breast and gastric cancers overexpressing c-erbB-2 protein have a greater metastatic potential and worse prognosis than tumors in which this protein is not overexpressed. The present study was undertaken to examine the significance of c-erbB-2 protein expression as a prognostic factor in c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.7.6.1229
更新日期:2000-11-01 00:00:00
abstract::We radiographically evaluated the response of primary lesions to chemotherapy in 101 patients with inoperable advanced gastric cancer. The median survival time in the 50 responders (49.5%) was 379 days, as compared with only 210 days in the 51 non-responders (50.1%) (p<0. 001). Morphologic changes of the gastric mucos...
journal_title:Oncology reports
pub_type: 临床试验,杂志文章
doi:10.3892/or.7.6.1279
更新日期:2000-11-01 00:00:00